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Khuroo M. S. Study of an epidemic of non-A, non-B hepatitis. Possibility of another human hepatitis virus distinct from post-transfusion non-A, non-B type. Am J Med. 1980;68(6):818-24.

By : Khuroo M. S.         Dated : 11/20/2015

 Am J Med. 1980 Jun;68(6):818-24.

Study of an epidemic of non-A, non-B hepatitis. Possibility of another human
hepatitis virus distinct from post-transfusion non-A, non-B type.

Khuroo MS.

A common source waterborne epidemic of viral hepatitis was studied in Kashmir
valley over the six month period from November 1978 to April 1979. Highly
sensitive serologic tests for hepatitis B and hepatitis A failed to reveal either
one as an etiologic agent of hepatitis. Of 16620 inhabitants of the area screened
four times in these six months, viral hepatitis developed in 1.65 per cent. In
addition, 27.3 per cent of 128 persons who had contacts with patients who had
viral hepatitis had biochemical features of anicteric hepatitis. The mode of
spread of the epidemic, length of incubation, clinical features and biochemical
test results of the patients studied resembled that of hepatitis A. These
findings were in contrast to that of non-A, non-B hepatitis following
transfusion, which closely resembles hepatitis B. The data strongly suggest the
possibility of another human hepatitis virus and established the fecal oral route
of its spread.


PMID: 6770682  [Indexed for MEDLINE]